| ncRNA name | HIWI2 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | siRNA transfection, qPCR, Western blot, ELISA, gelatin zymography |
| Expression pattern | associated |
| Functional description | Silencing HIWI2 reduced the expression of growth factors, VEGF and TGFβ1, and altered the expression of epithelial to mesenchymal transition (EMT) markers E-cadherin and αSMA. In addition, expression of MMP9 and cell migration was reduced in Si-HIWI2. |
| PubMed ID | 30145353 |
| Year | 2018 |
| Title | PIWI-like protein, HIWI2: A novel player in proliferative diabetic retinopathy. |
| Drug-related ncRNA | NO |
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